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Related Experiment Video

Updated: Jun 27, 2026

Murine Flexor Tendon Injury and Repair Surgery

Murine Flexor Tendon Injury and Repair Surgery

Published on: September 19, 2016

Tendon Inversion Improves Tendon-to-Bone Healing in a Rat Bicep Tenodesis Model.

Ting Cong¹, Thomas M Li², Dustin C Buller³

¹Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA; Veteran Affairs Pittsburgh Healthcare System, Pittsburgh, PA.

The Journal of Hand Surgery

|January 23, 2025

Summary

This summary is machine-generated.

Tendon inversion surgery improved tendon-to-bone healing in rats by disrupting the gliding epitendon surface. This technique enhances healing scores and collagen alignment for better surgical outcomes.

Keywords:

Lubricin rat model surgical technique tendon tendon-to-bone repair tenodesis

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Last Updated: Jun 27, 2026

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Published on: September 19, 2016

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Area of Science:

Orthopedic surgery
Biomaterials science
Regenerative medicine

Background:

Tendon-to-bone repair is challenging, with current methods failing to replicate native enthesis biomechanics.
Bone tunnel fixation is common, but healing at the interface requires improvement.

Purpose of the Study:

To investigate the effect of inside-out longitudinal tendon inversion on bone tunnel healing.
To test the hypothesis that tendon inversion removes the gliding epitenon to enhance interface healing.

Main Methods:

Forty male Sprague-Dawley rats underwent native tendon tenodesis (control) or tendon inversion tenodesis (experimental).
Evaluated biomechanical tensile strength, failure modes, tissue architecture via histology, and epitendinous lubricin disruption via immunohistochemistry at 8 weeks post-surgery.

Main Results:

Tendon inversion significantly increased maximum tensile strength compared to controls.
Reduced epitendinous lubricin and improved healing scores and collagen fibril alignment were observed in the experimental group.

Conclusions:

Longitudinal tendon inversion enhances tendon-to-bone healing in a rat model.
Disruption of the epitendinous surface is a key factor in improved healing, offering insights for surgical technique refinement.