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Bone healing stimulated by plasma factor XIII. Osteotomy experiments in sheep
Acta Orthopaedica Scandinavica
|February 1, 1985
Summary
Factor Thirteen enhanced bone healing in sheep after metatarsal osteotomy. Treated sheep showed significantly higher bone tensile strength and hydroxyapatite content compared to controls, indicating improved fracture repair.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Regenerative Medicine
Background:
- Fracture healing is a complex biological process.
- Osteotomy stabilization is crucial for bone repair.
- Factor XIII (FXIII) is a transglutaminase involved in blood coagulation and tissue repair.
Purpose of the Study:
- To investigate the effect of Factor Thirteen on bone healing after osteotomy.
- To evaluate biomechanical, histomorphological, and densitometric parameters of bone repair.
Main Methods:
- Sheep underwent midshaft osteotomy of the right metatarsal, stabilized with plate and screws.
- One group received postoperative Factor Thirteen injections; a control group received placebo.
- Bone healing was assessed after 8 weeks using biomechanical testing, histomorphology, and densitometry.
Main Results:
- Factor Thirteen treated bones exhibited significantly higher tensile strength than control bones.
- Increased tensile strength correlated with a higher number of osteons crossing the osteotomy gap.
- The hydroxyapatite content in the healing zone was 7.3% higher in the Factor Thirteen treated group.
Conclusions:
- Factor Thirteen supplementation significantly enhances bone healing and increases tensile strength after osteotomy in sheep.
- FXIII may promote bone regeneration by influencing osteon formation and mineralization.
- These findings suggest a potential therapeutic role for Factor Thirteen in orthopedic fracture repair.