Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nondisjunction01:21

Nondisjunction

3.7K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.7K
CRISPR01:59

CRISPR

49.3K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
49.3K
Teratogenicity01:07

Teratogenicity

2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ESHRE PGT Consortium data collection XXII-XXIV: PGT analyses from 2019 to 2021†.

Human reproduction (Oxford, England)·2026
Same author

A comprehensive review for defining cut-off values of oocyte, zygote, and embryo maturation arrest (OZEMA) due to maternal-effect genes: towards the establishment of clinical criteria.

Human reproduction (Oxford, England)·2026
Same author

ESHRE's key research priorities in infertility: maximizing impact on science, people and society†.

Human reproduction (Oxford, England)·2025
Same author

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility.

Nature communications·2024
Same author

An ESHG-ESHRE survey on the current practice of expanded carrier screening in medically assisted reproduction.

Human reproduction (Oxford, England)·2024
Same author

Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.

Human reproduction update·2024
Same journal

Expanding health insurance coverage for fertility preservation services among breast cancer patients.

Journal of assisted reproduction and genetics·2026
Same journal

Ubiquitinated proteomics reveals potential epigenetic-energy metabolism mechanisms in senescent ovarian granulosa cells of advanced maternal age.

Journal of assisted reproduction and genetics·2026
Same journal

Mapping the genetic and genomic landscape of assisted reproductive technology outcomes: a bibliometric analysis (2014-2025).

Journal of assisted reproduction and genetics·2026
Same journal

The impact of prior hormonal intrauterine device (IUD) use on endometrial lining thickness in the fertility clinic setting: a retrospective cohort study.

Journal of assisted reproduction and genetics·2026
Same journal

Identification of 46,XX/46,XY chimerism in a normal fertile male by low-pass copy number variation sequencing and NGS-based STR tests.

Journal of assisted reproduction and genetics·2026
Same journal

Platelet-rich plasma hydrogel supports long-term germ cell maintenance in rat testicular organotypic culture.

Journal of assisted reproduction and genetics·2026
See all related articles

Related Experiment Video

Updated: May 31, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.3K

PGT-A: what's it for, what's wrong?

Stéphane Viville1,2, Mohamed Aboulghar3,4

  • 1Laboratoire de Diagnostic Génétique, Hôpitaux Universitaires de Strasbourg, UF3472-Génétique de L'infertilité, 67000, Strasbourg, France. stephane.viville@unistra.fr.

Journal of Assisted Reproduction and Genetics
|January 23, 2025
PubMed
Summary
This summary is machine-generated.

Preimplantation genetic testing for aneuploidy (PGT-A) was developed to improve IVF success by selecting euploid embryos. However, current evidence suggests PGT-A offers minimal benefits and may even reduce IVF outcomes, questioning its clinical value.

Keywords:
Euploid embryo transferIVFLife birth ratesMiscarriageMosaic embryosPGT-APregnancy rates

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.0K
FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.7K

Related Experiment Videos

Last Updated: May 31, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.3K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.0K
FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.7K

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Embryology

Background:

  • Fetal aneuploidies increase with maternal age, leading to miscarriages.
  • Preimplantation genetic testing for aneuploidy (PGT-A) was introduced to improve IVF outcomes by selecting euploid embryos.
  • Despite widespread use for nearly 30 years, PGT-A's effectiveness remains debated.

Purpose of the Study:

  • To evaluate the clinical utility and effectiveness of PGT-A in assisted reproduction.
  • To critically assess the benefits and drawbacks of PGT-A based on available evidence.
  • To explore the ethical implications surrounding PGT-A practices.

Main Methods:

  • Review of studies examining PGT-A's impact on medically assisted reproduction (MAR) outcomes.
  • Analysis of studies comparing embryo transfer success rates versus intention-to-treat outcomes.
  • Exploration of ethical considerations related to PGT-A recommendations.

Main Results:

  • Initial studies suggested improved MAR outcomes, but used embryo transfer as the reference.
  • More recent intention-to-treat analyses show marginal or reduced IVF outcomes with PGT-A.
  • The clinical value of PGT-A is controversial and not consistently proven.

Conclusions:

  • PGT-A's effectiveness in improving IVF outcomes is not consistently demonstrated.
  • Evidence suggests PGT-A may offer limited benefits and potentially negative impacts on IVF success rates.
  • The study concludes that PGT-A should no longer be routinely offered to infertile couples.