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  3. Pgt-a: What's It For, What's Wrong?
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  3. Pgt-a: What's It For, What's Wrong?

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PGT-A: what's it for, what's wrong?

Stéphane Viville1,2, Mohamed Aboulghar3,4

  • 1Laboratoire de Diagnostic Génétique, Hôpitaux Universitaires de Strasbourg, UF3472-Génétique de L'infertilité, 67000, Strasbourg, France. stephane.viville@unistra.fr.

Journal of Assisted Reproduction and Genetics
|January 23, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Preimplantation genetic testing for aneuploidy (PGT-A) was developed to improve IVF success by selecting euploid embryos. However, current evidence suggests PGT-A offers minimal benefits and may even reduce IVF outcomes, questioning its clinical value.

Keywords:
Euploid embryo transferIVFLife birth ratesMiscarriageMosaic embryosPGT-APregnancy rates

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Embryology

Background:

  • Fetal aneuploidies increase with maternal age, leading to miscarriages.
  • Preimplantation genetic testing for aneuploidy (PGT-A) was introduced to improve IVF outcomes by selecting euploid embryos.
  • Despite widespread use for nearly 30 years, PGT-A's effectiveness remains debated.

Purpose of the Study:

  • To evaluate the clinical utility and effectiveness of PGT-A in assisted reproduction.
  • To critically assess the benefits and drawbacks of PGT-A based on available evidence.
  • To explore the ethical implications surrounding PGT-A practices.

Main Methods:

  • Review of studies examining PGT-A's impact on medically assisted reproduction (MAR) outcomes.
  • Analysis of studies comparing embryo transfer success rates versus intention-to-treat outcomes.
  • Exploration of ethical considerations related to PGT-A recommendations.

    • Main Results:

    • Initial studies suggested improved MAR outcomes, but used embryo transfer as the reference.
    • More recent intention-to-treat analyses show marginal or reduced IVF outcomes with PGT-A.
    • The clinical value of PGT-A is controversial and not consistently proven.

    Conclusions:

    • PGT-A's effectiveness in improving IVF outcomes is not consistently demonstrated.
    • Evidence suggests PGT-A may offer limited benefits and potentially negative impacts on IVF success rates.
    • The study concludes that PGT-A should no longer be routinely offered to infertile couples.