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Efficacy of Poloxamer 188 in Carboplatin-Induced Aplastic Anemia Model in CBA Mice
A V Bervinova1,2, V A Palikov1, N A Borozdina3
1Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Branch, Russian Academy of Sciences, Pushchino, Russia.
Abstract:
Poloxamer 188 (P188) was tested for effect on medullary hematopoiesis in aplastic anemia. P188 was administered to CBA mice with developing anemia via oral gavage at doses of 10, 100, and 500 mg/kg. A dose-dependent effect was observed, including an increase in erythrocyte count, hemoglobin, and reticulocyte count. The parameters remained low and suggested mild anemia on day 21 in a group treated with carboplatin. P188 was assumed to exert a beneficial effect on the blood cell composition, which is distorted by cytostatic drugs.
