Related Experiment Video

Updated: May 31, 2025

A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs
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A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs

Published on: July 20, 2017

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Decoding the Role of Kinesin Superfamily Proteins in Glioma Progression

Mohamed J Saadh1, Zahraa Sabah Ghnim2, Morug Salih Mahdi3

  • 1Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan. mohamedjsaadh@gmail.com.

Journal of Molecular Neuroscience : MN
|January 23, 2025
PubMed

Insights

Kinesin superfamily proteins (KIFs) are crucial for glioma development and progression. Targeting KIFs offers a promising new strategy for treating aggressive brain tumors.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Glioma is an aggressive brain tumor with limited treatment options.
  • Kinesin superfamily proteins (KIFs) are motor proteins vital for cell functions implicated in cancer.
  • Understanding KIFs' role in glioma is critical for developing new therapies.

Purpose of the Study:

  • To review the role of KIFs in glioma pathogenesis.
  • To explore KIFs as potential therapeutic targets for glioma.
  • To examine the interplay of KIFs with non-coding RNAs and signaling pathways in glioma.

Main Methods:

  • Literature review of Kinesin superfamily proteins (KIFs) in glioma.
  • Analysis of KIFs' influence on glioma cell proliferation, invasion, migration, and metastasis.
  • Examination of KIFs' regulation of cell cycle and signaling pathways (PI3K-Akt, Wnt/β-catenin, Hedgehog).
  • Investigation of KIFs' interaction with non-coding RNAs (circRNAs, miRNAs).
  • Review of current KIF-targeting therapies (immunotherapy, chemotherapy, small-molecule inhibitors).

Main Results:

  • KIFs significantly contribute to glioma progression by influencing cell proliferation, invasion, migration, and metastasis.
  • KIFs regulate critical cell cycle and signaling pathways involved in glioma.
  • KIFs interact with non-coding RNAs, impacting glioma development.
  • Various therapeutic strategies targeting KIFs show potential for improving glioma treatment outcomes.

Conclusions:

  • Kinesin superfamily proteins (KIFs) play a multifaceted role in glioma pathogenesis.
  • KIFs represent promising novel therapeutic targets for glioma treatment.
  • Targeting KIFs, in combination with other strategies, may enhance outcomes for glioma patients.
Keywords:
GlioblastomaGliomaKinesin superfamilyMotor proteinsSignaling pathway

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