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Specialized Characteristics of Cardiac Muscles

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...

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Updated: May 31, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic Myocarditis: A Concise Review.

Ashlee M Asada¹, Rami Kahwash², Vincenzo Trovato³

¹Division of Internal Medicine, The Ohio State University, Columbus, OH, USA. ashlee.asada@osumc.edu.

Current Cardiology Reports

|January 23, 2025

Summary

This summary is machine-generated.

Eosinophilic myocarditis (EM) is a rare inflammatory heart condition. Targeted biologic therapies show promise for refractory cases, but further research is needed.

Keywords:

Benralizumab Eosinophilic granulomatosis with polyangiitis Eosinophilic myocarditis Hypereosinophilic syndrome Mepolizumab

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Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

Area of Science:

Cardiology
Immunology
Inflammatory Diseases

Background:

Eosinophilic myocarditis (EM) is a rare, heterogeneous inflammatory heart disease.
Existing literature consists of case reports and small series, lacking standardized treatment protocols.
This review synthesizes current knowledge on EM, including refractory disease management.

Purpose of the Study:

To provide a concise summary of the current literature on eosinophilic myocarditis.
To update on maintenance therapy strategies for refractory or recurrent EM.
To highlight emerging treatment options and research needs.

Main Methods:

Literature review of observational studies and case series on eosinophilic myocarditis.
Analysis of treatment outcomes for refractory and recurrent EM.
Synthesis of data on biologic therapies like mepolizumab and benralizumab.

Main Results:

Observational studies suggest clinical benefit of mepolizumab and benralizumab in refractory EM.
Eosinophilic myocarditis presents with diverse etiologies and clinical manifestations.
Current treatment approaches for EM are not standardized due to a lack of large-scale trials.

Conclusions:

Targeted biologic therapies demonstrate potential in managing refractory eosinophilic myocarditis.
Prospective studies are essential to validate the efficacy of these biologics in EM.
Standardization of EM treatment requires further investigation and evidence generation.