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Antibody-coating and haemagglutination by Staphylococcus saprophyticus
Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology
|February 1, 1985
Summary
Antibody-coated Staphylococcus saprophyticus (S. saprophyticus) were found in most urine samples. Their presence correlated with longer symptom duration but not with urinary tract symptoms, proteinuria, or haematuria.
Area of Science:
- Urology
- Microbiology
- Immunology
Background:
- Staphylococcus saprophyticus (S. saprophyticus) is a common cause of urinary tract infections.
- Antibody coating of bacteria in urine may indicate an immune response.
- The clinical significance of antibody-coated bacteria in S. saprophyticus infections requires further clarification.
Purpose of the Study:
- To investigate the occurrence and clinical relevance of antibody-coated Staphylococcus saprophyticus in urine specimens.
- To determine the correlation between antibody-coated bacteria and clinical symptoms, proteinuria, and haematuria.
- To assess the relationship between direct haemagglutination by S. saprophyticus and antibody coating.
Main Methods:
- Analysis of 28 urine specimens for antibody-coated cocci (IgG, IgA, IgM) using immunofluorescence.
- Correlation analysis with clinical data, including urinary tract symptoms, duration of symptoms, proteinuria, and haematuria.
- Testing for direct haemagglutination of sheep erythrocytes in 61 washed urine sediments containing S. saprophyticus.
Main Results:
- Antibody-coated cocci were detected in 21 (IgG), 20 (IgA), and 9 (IgM) of 28 urine specimens.
- No correlation was found between antibody-coated cocci and upper/lower urinary tract symptoms, proteinuria, or haematuria.
- Antibody-coated cocci were more frequent in patients with symptoms lasting 7 days or longer.
- Direct haemagglutination was observed in 30 of 61 specimens, with a significant correlation between non-haemagglutinating specimens and antibody-coated bacteria.
Conclusions:
- Antibody coating of Staphylococcus saprophyticus occurs frequently in urine, particularly with longer symptom duration.
- Antibody coating does not appear to correlate with specific urinary tract symptoms or markers like proteinuria/haematuria.
- The association between non-haemagglutinating properties and antibody coating suggests a complex interaction in S. saprophyticus infections.