Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

160
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
160
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

439
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
439
  1. Home
  3. Research Domains
  5. Indigenous Studies
  7. Te Hauora Me Te Oranga O Te Māori (māori Health And Wellbeing)
  9. Te Whaikaha Me Te Māori (māori And Disability)
  11. Tiaogeng Decoction Improves Mild Cognitive Impairment In Menopausal App/ps1 Mice Through The Ers/nf-κ B/aqp1 Signaling Pathway

Tiaogeng decoction improves mild cognitive impairment in menopausal APP/PS1 mice through the ERs/NF-κ b/AQP1 signaling pathway

Xuan-Ling Li1, Zhi-Heng Lin1, Si-Ru Chen1

  • 1Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|January 23, 2025

Related Experiment Videos

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.0K
Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

437
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

821

View abstract on PubMed

Summary
This summary is machine-generated.

Tiao Geng Decoction (TGD) may improve mild cognitive impairment (MCI) in postmenopausal women by regulating estrogen receptors and inhibiting the NF-κb pathway, reducing neuroinflammation and Aβ deposition. This traditional Chinese medicine shows potential for preventing Alzheimer's disease.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Mild cognitive impairment (MCI) risk increases with postmenopausal estrogen deficiency.
  • Tiao Geng Decoction (TGD) exhibits potential antioxidant and anti-apoptotic properties.
  • Mechanisms of TGD in postmenopausal MCI remain unclear.

Purpose of the Study:

  • Investigate TGD's pharmacological mechanisms in preventing postmenopausal MCI.
  • Explore TGD's effects on estrogen deficiency-induced cognitive decline.
  • Identify molecular pathways targeted by TGD.

Main Methods:

  • RNA sequencing and single-cell sequencing in mouse models.
  • Ovariectomy to induce estrogen deficiency and MCI.
  • Western blotting, RT-qPCR, and immunofluorescence for molecular analysis.
Keywords:
AβERs/NF-κb/AQP1signal pathwayMenopauseMild cognitive impairment

Related Experiment Videos

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research
03:26

Author Spotlight: Improving Anesthesia Protocols for Enhanced Mouse Acupuncture Research

Published on: December 8, 2023

1.0K
Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

437
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

821
  • Assessment of spatial learning and memory.

    • Main Results:

    • Estrogen deficiency activated NF-κb signaling, NLRP3 inflammasome, and BACE1, leading to neuroinflammation and cognitive decline.
    • TGD intervention improved spatial learning and memory in MCI mice.
    • TGD stimulated estrogen receptor (ERα/ERβ) secretion, inhibited NF-κb, downregulated BACE1, and reduced NLRP3 inflammasome and Aβ deposition.
    • TGD facilitated AQP1 expression and lowered Aβ sedimentation.

    Conclusions:

    • A low estrogen environment is strongly linked to MCI development.
    • TGD may act via the ERs/NF-κb/AQP1 pathway to improve MCI.
    • TGD shows promise as a novel therapeutic for menopausal MCI and potentially preventing AD.
    Neuroinflammatory damage
    Tiaogeng decoction