Related Experiment Video
Updated: May 31, 2025

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
Published on: May 26, 2023
Transcriptomic modifications across the genome and potential hazards of pulmonary fibrosis caused by metal-organic
Yule Zhang1, Zhijin Yang1, Mengya Chen1
1Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, Shanghai Engineering Research Center of Environmental Biosafety Instruments and Equipment, University of Shanghai for Science and Technology, Shanghai 200093, PR China.
Abstract:
Metal-Organic Frameworks (MOFs) have shown great promise in environmental protection, owing to their exceptional properties including ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. However, emerging evidence from experimental studies indicates that MOFs have side effects on human health due to metal ions doping, resulting in excessive reactive oxygen species (ROS) production, pro-inflammatory responses, and liver fibrosis. In this study, we investigated the impact of MOF-199 on human bronchial epithelial (HBE) cells by using transcriptome sequencing analysis. The results indicated that the stimulation of MOF-199 enhanced ROS generation, upregulated cytoplasmic Ca2+ levels, then activated the Grb2/SOS/Ras/Raf pathway, induced cell apoptosis, and ultimately resulted in lung fibroblasts through TGF-β secretion. The results were validated in vitro and in vivo. Therefore, it is necessary to carefully evaluate the nanosafety of MOF-199 in environment treatments.
More Related Videos
Related Concept Videos
RNA Stability
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation

