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Updated: May 31, 2025

Perspectives on Neuroscience
Published on: July 31, 2007
What if what matters is emergent?
1Department of Neurology, Washington University in Saint Louis, St. Louis, MO, USA.
Abstract:
In this issue of Neuron, Ruggiero et al.1 demonstrate that hippocampal networks maintain a stable mean firing rate despite unstable individual units. This homeostatic control operates through NMDAR-eEF2K-BDNF signaling in parvalbumin interneurons. Their findings highlight a mechanism by which cellular machinery maintains emergent network properties, bridging molecular mechanisms with network-level computation.
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