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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Prognostic significance of ventricular late potentials in coronary artery disease

M Zimmermann, R Adamec, P Simonin

    American Heart Journal
    |April 1, 1985
    PubMed

    Insights

    Ventricular late potentials (VLPs) are common in coronary artery disease (CAD) and significantly increase the risk of sustained ventricular tachycardia/fibrillation (VT/VF), especially in patients with ventricular aneurysm or a history of VT/VF.

    Area of Science:

    • Cardiology
    • Electrophysiology

    Background:

    • Ventricular late potentials (VLPs) are potential indicators of arrhythmic risk.
    • Their prevalence and prognostic significance in coronary artery disease (CAD) require further investigation.

    Purpose of the Study:

    • To determine the prevalence of VLPs in CAD patients.
    • To assess the prognostic value of VLPs for sustained ventricular tachycardia/fibrillation (VT/VF).

    Main Methods:

    • High-gain electrocardiography (ECG) and signal-averaging techniques were used.
    • VLPs were assessed in 92 CAD patients, with follow-up for VT/VF events.

    Main Results:

    • VLPs were detected in 35% of CAD patients, with higher prevalence in those with ventricular aneurysm (48%) or prior VT/VF (82%).
    • Patients with VLPs had a significantly higher incidence of sustained VT/VF (31% vs 2%) and mortality from VT/VF (p < 0.01).
    • VLP presence, length, and low ejection fraction were associated with increased arrhythmic risk.

    Conclusions:

    • VLPs are prevalent in CAD and are a significant predictor of future sustained VT/VF.
    • VLP detection aids in risk stratification for sudden cardiac death in CAD patients.

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