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Association between Maternal Lead Exposure from Seafood Consumption and Neurodevelopment: A Systematic Review.

Arin A Balalian1, Maureen K Spill1, Rachel C Thoerig1

  • 1Texas A&M Agriculture, Food and Nutrition Evidence Center, Fort Worth, TX, United States.

Advances in Nutrition (Bethesda, Md.)
|January 23, 2025
PubMed
Summary

Maternal seafood consumption during pregnancy and lactation (PL) may expose children to lead (Pb), but evidence linking this exposure to neurodevelopmental outcomes is limited and uncertain. Further research is needed to clarify potential risks and benefits.

Keywords:
Pbcognitionfishleadneurodevelopmentpregnancy and lactationseafood

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Area of Science:

  • Environmental Health
  • Neurodevelopmental Pediatrics
  • Maternal-Fetal Medicine

Background:

  • Maternal seafood intake during pregnancy and lactation (PL) provides essential nutrients but also poses a risk of exposure to toxins like lead (Pb).
  • The impact of Pb exposure from seafood during PL on children's neurodevelopment remains unclear, necessitating a comprehensive review of existing evidence.

Conclusions:

  • The current evidence is insufficient to establish a direct association between Pb exposure from seafood intake during PL and child neurodevelopment.
  • The overall certainty of evidence is very low due to a limited number of studies, risk of bias, and other limitations.
  • Higher seafood intake, in one study, suggested positive developmental outcomes, though significance varied.