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Updated: May 31, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Aculeanoids A-D, the second 17-nor fusicoccane diterpenoids with immunosuppressive activity from Aspergillus
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China; Department of Radiation Medicine and Environment Medicine, China Institute for Radiation Protection, Taiyuan, 030006, People's Republic of China.
Abstract:
Chemical investigation on the secondary metabolites of Aspergillus aculeatus led to the identification of ten modified fusicoccane-type diterpenoids aculeanoids A-J (1-10). Their structures and absolute configurations were characterized by comprehensive spectroscopic analysis, DP4+ analysis, Mo2(OAc)4-induced ECD, single-crystal X-ray diffractions, and ECD calculations. Compounds 1-4 belong to a rare class of 17-nor fusicoccane diterpenoids, with only one previously reported example. Biologically, compounds 6, 7, and 10 exhibited significant immunosuppressive activities against con A-induced T cell proliferation with IC50 values ranging from 2.44 to 5.26 μM and LPS-induced B cell proliferation with IC50 values ranging from 4.18 to 5.78 μM, which provided more possibilities with the treatment of organ transplantation and various autoimmune diseases.
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