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The bone-vascular axis: the link between osteoporosis and vascular calcification
Yue Sun1,2, Dageng Huang3, Yan Zhang4,5
1Department of Orthopaedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Molecular and Cellular Biochemistry
|January 23, 2025
Summary
Osteoporosis and vascular calcification are linked metabolic diseases in aging individuals. Understanding their shared mechanisms, like aging and metabolism, is key for prevention and treatment.
Area of Science:
- Gerontology
- Metabolic Diseases
- Biomedical Science
Background:
- Osteoporosis and vascular calcification are prevalent chronic metabolic diseases in aging populations.
- Their increasing incidence warrants significant scientific and clinical attention.
- Growing evidence suggests a strong correlation between these conditions in pathogenesis and underlying mechanisms.
Purpose of the Study:
- To review the current understanding of the correlation between osteoporosis and vascular calcification.
- To elucidate the shared underlying mechanisms connecting these two diseases.
- To highlight the complexity of the bone-vascular axis for novel therapeutic strategies.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of studies focusing on shared etiological factors.
- Examination of molecular and cellular pathways involved in both conditions.
Main Results:
- Identified shared mechanisms including aging, oxidative stress, inflammation, lipid and mineral metabolism, and autophagy.
- Highlighted the intricate interplay within the bone-vascular axis.
- Confirmed that osteoporosis and vascular calcification are not independent but interconnected diseases.
Conclusions:
- Osteoporosis and vascular calcification share common underlying mechanisms.
- Understanding the bone-vascular axis offers new avenues for preventing and treating these age-related diseases.
- Further research into these shared pathways is crucial for clinical advancements.
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