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Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular
Mohsen Rezaee1, Farzam Kamrani2, Mobina Imannezhad2
1Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Insights
The triglyceride-total cholesterol-body weight index (TCBI) predicts cardiovascular disease (CVD) mortality, unlike other indices. Traditional atherogenic indices like CRI-I and CRI-II show stronger predictive power for CVD risk assessment.
Area of Science:
- Cardiology
- Public Health
- Biostatistics
Background:
- Cardiovascular disease (CVD) is the leading global cause of death.
- Atherogenic indices are established CVD risk factors.
- The triglyceride-total cholesterol-body weight index (TCBI) is a novel index incorporating key CVD risk factors.
Purpose of the Study:
- To evaluate the predictive capability of established atherogenic indices and the novel TCBI for CVD incidence and mortality.
- To compare the predictive performance of TCBI against traditional indices.
Main Methods:
- A prospective cohort study utilized data from 9704 healthy participants in the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study.
- Baseline variables were collected, and TCBI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), and Castelli risk indices (CRI-I & II) were calculated.
- A 10-year follow-up period assessed CVD incidence and mortality.
Main Results:
- TCBI, CRI-I, and CRI-II showed a significant positive association with CVD mortality after 10 years.
- No significant relationship was found between TCBI and CVD incidence.
- AIP and AC were not associated with CVD mortality.
Conclusions:
- TCBI is associated with increased CVD mortality, outperforming AC and AIP in this regard.
- Traditional indices, CRI-I and CRI-II, demonstrated superior predictive capabilities for CVD mortality compared to TCBI.
- Enhancements to the TCBI formula are recommended to improve its efficacy in CVD risk assessment.
Background:
Cardiovascular disease (CVD), a non-communicable condition, stands as the primary cause of death globally. This study seeks to evaluate the predictive power of atherogenic indices, which are recognized for their influence on CVD, alongside a newly developed index encompassing all three principal risk factors for CVD, referred to as the triglyceride-total cholesterol-body weight index (TCBI). The primary outcomes evaluated include both the incidence and mortality rates associated with CVD.
Methods:
A prospective cohort study was conducted on Mashhad stroke and heart atherosclerotic disorder (MASHAD) study data, involving 9704 healthy participants. Baseline variables were measured, and TCBI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli risk index I and II (CRI-I & II) were calculated using specific formulas.
Results:
Following a 10-year follow-up period, a significant positive relationship was observed between TCBI (HR: 1.078, 95% CI: 1.012-1.15), CRI-I (HR: 1.16, 95% CI: 1.007-1.337), and CRI-II (HR: 1.199, 95% CI: 1.001-1.437) with CVD mortality. However, no significant relationship was identified between TCBI and atherogenic indices related to CVD incidence, and neither AIP nor AC was associated with CVD mortality.
Conclusion:
In conclusion, TCBI, in contrast to AC and AIP, was linked to increased CVD mortality. However, the more substantial predictive capabilities of CRI-I and CRI-II compared to TCBI emphasize the importance of traditional atherogenic indices for accurate risk assessment. These findings underscore the necessity of enhancing the TCBI formula to improve its effectiveness in assessing CVD risk.
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