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Peritoneal dialysis: physiology, current applications and future directions.

K D Nolph

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1979
    PubMed
    Summary

    Peritoneal dialysis systems are sophisticated but inefficient for small solute removal. Continuous ambulatory peritoneal dialysis (CAPD) offers a solution by trading efficiency for time, with promising but not fully answered questions.

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    Area of Science:

    • Nephrology
    • Biomedical Engineering

    Background:

    • Peritoneal dialysis (PD) systems function as sophisticated dialyzers, mimicking kidney functions like capillary regulation and membrane permeability.
    • These systems surpass extracorporeal hemodialysis in complexity but face inherent limitations in small solute removal efficiency due to pore size and fluid film resistances.

    Purpose of the Study:

    • To evaluate the preliminary findings and potential of continuous ambulatory peritoneal dialysis (CAPD) over the first two years of its application.
    • To address initial questions regarding the efficacy and practicality of CAPD as a dialysis modality.

    Main Methods:

    • The study involved a two-year observational period of patients undergoing CAPD.
    • Data analysis focused on assessing the performance and outcomes of the CAPD system in managing dialysis.

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    Main Results:

    • CAPD effectively overcomes the intrinsic inefficiency of standard peritoneal dialysis by utilizing extended treatment times.
    • Preliminary data from the first two years indicate that CAPD addresses many initial concerns, demonstrating its viability.

    Conclusions:

    • Continuous ambulatory peritoneal dialysis (CAPD) presents a viable strategy to enhance solute removal in peritoneal dialysis by extending treatment duration.
    • While CAPD shows significant potential, further research is required to fully elucidate its long-term benefits and address remaining questions.