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Updated: Jul 20, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
The intricate relationship between SUMOylation and gliomas: a review with a perspective on natural compounds
Anderson Togni1, Tetsade Piermartiri2, Carla Inês Tasca2
1Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Abstract:
Gliomas are tumours that affect the nervous system, with glioblastoma, also known as grade IV astrocytoma, being the most aggressive type, associated with poor prognosis. Glioblastoma is characterised by its highly invasive nature, rapid growth, and resistance to conventional chemotherapy and radiation treatments, resulting in a median survival of about 14 months. To improve patient outcomes, novel therapeutic approaches are needed. Targeting SUMOylation, a post-translational modification involving the attachment of Small Ubiquitin-like Modifier (SUMO) proteins to lysine residues in target proteins, is emerging as a promising strategy. SUMOylation regulates various biological processes, including the cell cycle, apoptosis, and senescence. Dysregulation of this pathway has been linked to glioblastoma tumorigenesis, as well as the invasion and proliferation of glioblastoma cells. Therefore, focusing on the SUMOylation pathway offers the potential for developing innovative therapeutic strategies, including the use of natural compounds as adjuvant therapies, to address glioblastoma more effectively.
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