Diffuse papillomatosis of the gallbladder

Herein we document the first case of diffuse papillomatosis of the gallbladder. The lesion occurred in a patient with a history of chronic ulcerative colitis and sclerosing cholangitis with secondary biliary cirrhosis. Of further interest was the presence of Paneth cells in the gallbladder lesion. The unique aspects of this case as well as the significance of papillomas or adenomas of the gallbladder are discussed.