Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxidative Stress and Nrf2 Signaling Role in Oral Squamous Cell Carcinoma: A Double-Edged Sword.

Biology of the cell·2026
Same author

Corrosion behavior of selective laser melted NiTi shape memory alloy.

Scientific reports·2026
Same author

Retraction notice to "Corrigendum to "Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators" [Biomed. Pharmacother. 114 (2019) 108777]" [Biomedicine & Pharmacotherapy 186 (2025) 117988].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Retraction notice to "Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3<sup>rd</sup> degree burn mice by inhibiting inflammatory mediators" [Biomedicine & Pharmacotherapy 114 (2019) 108777].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Circulating Inflammation-Related Proteins Linked to Corneal Neuroimmune Measures, Neuropathy Deficits, and Symptoms in Type 2 Diabetes.

Journal of the peripheral nervous system : JPNS·2026
Same author

Prenatal exercise interventions result in subtle changes in the human breast milk metabolome and lipidome 7-14 days postpartum: exploratory analyses of the FitMum randomized controlled trial.

International breastfeeding journal·2026
Same journal

Immunohistochemistry (IHC) Versus Genomic Profiling in Cancer: Roles in Precision Medicine.

Cureus·2026
Same journal

Pediatric Nasal Tip Reconstruction After a Donkey Bite Using an Expanded Paramedian Forehead Flap With Conchal Cartilage Grafts: A Case Report.

Cureus·2026
Same journal

Splenic Rupture: A Delayed and Rare Complication of Colonoscopy.

Cureus·2026
Same journal

Super-refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome Triggered by Influenza A: A Pediatric Case Report.

Cureus·2026
Same journal

Comparative Evaluation of Serum Peroxiredoxin 2 (PRDX2), Serum Peroxiredoxin 4 (PRDX4), and Plasma Methylated Septin 9 (mSEPT9) Levels Against Conventional Biomarkers for Early Detection of Colorectal Cancer: A Study Protocol.

Cureus·2026
Same journal

Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disease: A Narrative Review.

Cureus·2026
See all related articles

Related Experiment Video

Updated: May 31, 2025

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
00:20

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

51.2K

Outcomes of Reconstructive Surgery Using Vacuum-Assisted Closure in Patients With Complex Wounds.

Ayesha Rehman1, Ayesha Kausar2, Shahan Saleem3

  • 1Surgery, Divisional Headquarter Hospital, Mirpur, PAK.

Cureus
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

Vacuum-assisted closure (VAC) therapy shows promise for complex wounds but success depends on patient comorbidities and wound type. Further research is needed to optimize VAC protocols for better outcomes.

Keywords:
comorbiditiescomplex woundsreconstructive surgerytreatment outcomesvacuum-assisted closure

More Related Videos

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:49

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

661
Vessel-sparing Excision and Primary Anastomosis
08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.3K

Related Experiment Videos

Last Updated: May 31, 2025

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
00:20

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

51.2K
Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:49

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

661
Vessel-sparing Excision and Primary Anastomosis
08:09

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

11.3K

Area of Science:

  • Surgical Reconstruction
  • Wound Healing
  • Biomedical Engineering

Background:

  • Complex wounds present significant challenges in reconstructive surgery.
  • Comorbidities like obesity and diabetes, along with specific wound characteristics, impact healing.
  • Vacuum-assisted closure (VAC) therapy is a widely used technique for managing complex wounds.

Purpose of the Study:

  • To evaluate the effectiveness of reconstructive surgery combined with vacuum-assisted closure (VAC) therapy in patients with complex wounds.
  • To identify factors influencing surgical outcomes and complications in this patient cohort.

Main Methods:

  • A study involving 60 patients with complex wounds undergoing reconstructive surgery and VAC therapy.
  • Analysis of patient demographics, comorbidities (obesity, diabetes, cardiovascular disease), and wound types (diabetic ulcers, pressure ulcers).
  • VAC therapy parameters (continuous/intermittent mode, pressure 50-149 mmHg) were recorded, alongside pre- and post-operative laboratory markers.

Main Results:

  • Common comorbidities included obesity (26.7%) and diabetes (25.0%).
  • The most frequent complications were infection (21.7%) and hemorrhage (15.0%), with surgical site type significantly associated with complications.
  • Surgical outcomes varied, with 23.3% partially healed wounds and 28.3% reopened wounds.

Conclusions:

  • VAC therapy is beneficial for complex wounds, but patient comorbidities and wound characteristics are critical determinants of success.
  • Optimizing VAC therapy protocols is essential for improving outcomes in patients with complex wounds.
  • Further research is warranted to refine treatment strategies for diverse wound etiologies and patient profiles.