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High-risk Pseudomonas aeruginosa clones harboring β-lactamases: 2024 update
Verónica Roxana Flores-Vega1,2, Santiago Partida-Sanchez3,4, Miguel A Ares5
1Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Abstract:
Carbapenem-resistant Pseudomonas aeruginosa is defined by the World Health Organization as a "high priority" in developing new antimicrobials. Indeed, the emergence and spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacteria increase the morbidity and mortality risk of infected patients. Genomic variants of P. aeruginosa that display phenotypes of MDR/XDR have been defined as high-risk global clones. In this mini-review, we describe some international high-risk clones that carry β-lactamase genes that can produce chronic colonization and increase infected patients' morbidity and mortality rates.
Insights
Carbapenem-resistant Pseudomonas aeruginosa, a high-priority pathogen, poses significant risks due to multidrug resistance. This review highlights high-risk clones contributing to patient morbidity and mortality.
Area of Science:
- Microbiology
- Infectious Diseases
- Genomics
Background:
- Carbapenem-resistant Pseudomonas aeruginosa is a critical global health threat.
- Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains increase patient morbidity and mortality.
- Genomic variants, termed high-risk global clones, are associated with these resistance phenotypes.
Purpose of the Study:
- To review international high-risk clones of Pseudomonas aeruginosa.
- To describe the role of beta-lactamase genes in these clones.
- To discuss their impact on chronic colonization, morbidity, and mortality.
Main Methods:
- Literature review of genomic and clinical data.
- Focus on international high-risk clones of P. aeruginosa.
- Analysis of beta-lactamase gene carriage and associated phenotypes.
Main Results:
- Identification of specific international high-risk clones of P. aeruginosa.
- Association of these clones with beta-lactamase genes.
- Evidence linking these clones to chronic colonization and increased patient risk.
Conclusions:
- High-risk clones of carbapenem-resistant Pseudomonas aeruginosa are a major concern.
- Beta-lactamase genes in these clones contribute to treatment challenges.
- Effective antimicrobial development is crucial to combat these resistant strains.
