Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyclonal antibodies targeting defined epitopes on cancer biomarker MUC16.

Analytical and bioanalytical chemistry·2026
Same author

Corrigendum to "The effect of gestational diabetes on maternal and neonatal outcomes" [Taiwan J Obstet Gynecol 65 (2026) 256-264].

Taiwanese journal of obstetrics & gynecology·2026
Same author

The effect of gestational diabetes on maternal and neonatal outcomes.

Taiwanese journal of obstetrics & gynecology·2026
Same author

Effects of Image Degradation on Deep Neural Network Classification of Scaphoid Fracture Radiographs: Comparison Study of Different Noise Types.

JMIR medical informatics·2026
Same author

Arterialized-Venous Flap for Soft Tissue Reconstruction for recalcitrant Dupuytren Contracture.

Plastic and reconstructive surgery·2025
Same author

Characterization of M11-like and OC125-like Monoclonal Antibody Binding to CA125 Tandem Repeats.

Biosensors·2025

Related Experiment Video

Updated: May 31, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

441

Reverse Fragility Index in Plastic Surgery Randomized Controlled Trials.

Rodney Ahdoot1,2, Trista M Benítez1,2, Chien-Wei Wang2

  • 1From the University of Michigan Medical School, Ann Arbor, MI.

Plastic and Reconstructive Surgery. Global Open
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

The reverse fragility index (RFI) reveals that many non-significant plastic surgery trial results are fragile. Few event changes could alter these findings, highlighting the need for careful interpretation of null results in randomized controlled trials (RCTs).

More Related Videos

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
08:05

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

7.3K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

351

Related Experiment Videos

Last Updated: May 31, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

441
A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
08:05

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

7.3K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

351

Area of Science:

  • Plastic Surgery
  • Medical Statistics
  • Clinical Trials

Background:

  • The reverse fragility index (RFI) assesses the robustness of statistically nonsignificant findings in randomized controlled trials (RCTs).
  • RFI quantifies the minimum number of events needed to shift a nonsignificant result to statistical significance.
  • This study investigates the RFI in plastic surgery RCTs to evaluate the neutrality of nonsignificant outcomes.

Purpose of the Study:

  • To apply the reverse fragility index (RFI) to statistically nonsignificant randomized controlled trials (RCTs) in plastic surgery.
  • To assess the robustness and neutrality of null findings within plastic surgery research.
  • To determine if nonsignificant results in plastic surgery RCTs are prone to change with minimal event alterations.

Main Methods:

  • A systematic literature search identified RCTs in top plastic surgery journals (Jan 2000-Mar 2023).
  • The Fisher exact test calculated the RFI for primary outcomes.
  • Bivariate analysis explored associations between trial characteristics and RFI.

Main Results:

  • Forty RCTs with 65 primary outcomes were analyzed; median sample size was 76 participants.
  • The median RFI was 4, indicating few event changes could reverse statistical non-significance.
  • Many studies lacked statistical power analysis (21/40) or clear reporting of loss to follow-up (12/40).

Conclusions:

  • Nonsignificant results in plastic surgery RCTs often appear fragile, relying on a small number of events.
  • The RFI serves as a valuable metric to complement P-values for assessing the neutrality of null clinical trial findings.
  • This highlights the importance of cautious interpretation of nonsignificant results in plastic surgery research.