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Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases

Wenyan Zhou1, Yan Yi2, Wenyu Cao3

  • 1Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Frontiers in Pharmacology
|January 24, 2025
PubMed

Insights

N7-methylguanosine (m7G) modification is crucial for RNA regulation. Enzymes METTL1/WDR4 and QKI are linked to digestive cancers and ulcerative colitis, highlighting their roles in disease.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Gastroenterology

Background:

  • N7-methylguanosine (m7G) is a prevalent RNA modification vital for RNA stability, translation, and ribosome recognition.
  • The m7G modification is catalyzed by methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4) complex.
  • Quaking (QKI) protein recognizes internal m7G-methylated mRNA, regulating translation and stability.

Purpose of the Study:

  • To review the latest research on the roles of m7G methyltransferase (METTL1/WDR4) and recognition enzyme (QKI) in digestive diseases.
  • To explore the association of m7G modification-related enzymes with digestive cancers and inflammatory conditions.

Main Methods:

  • Literature review of recent studies.
  • Analysis of research on METTL1/WDR4 and QKI in the context of digestive diseases.
  • Focus on findings related to colorectal cancer, liver cancer, and ulcerative colitis.

Main Results:

  • m7G modification enzymes METTL1/WDR4 and QKI are implicated in the pathogenesis of digestive cancers.
  • These enzymes also play a role in other digestive diseases, such as ulcerative colitis.
  • Recent studies reveal significant associations between m7G-related enzymes and digestive disease progression.

Conclusions:

  • METTL1/WDR4 and QKI are key players in the molecular mechanisms underlying digestive diseases.
  • Targeting m7G modification pathways may offer novel therapeutic strategies for digestive cancers and inflammatory bowel diseases.
  • Further research is warranted to fully elucidate the complex roles of m7G modification in digestive health and disease.
Keywords:
METTL1QKIWDR4cancerdigestive diseasesm7G

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