Related Experiment Video
Updated: Aug 2, 2026
08:14
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening
Published on: October 26, 2017
Extrahepatic and Circulating miR-122: Diagnostic Implications and Future Directions
Rachel Sarah Royfman1, Joseph Riley McTague2, Meghana Ranabothu3
1Department of Medicine, The Ohio State University, Columbus, OH, USA.
Microrna (Shariqah, United Arab Emirates)
|January 24, 2025
Summary
MicroRNA-122 (miR-122) is crucial for gene regulation. This review compiles current knowledge on miR-122
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- MicroRNAs (miRNAs) regulate gene expression.
- miR-122 was initially identified as liver-specific.
- miR-122 is found in various extrahepatic tissues.
Purpose of the Study:
- To review the role of miR-122 in extrahepatic tissues.
- To compile information on miR-122 in health and disease.
- To highlight recent advancements in understanding extrahepatic miR-122 physiology.
Main Methods:
- Literature review of recent research on miR-122.
- Compilation of existing data on miR-122 expression and function.
- Analysis of miR-122's role in various tissues.
Main Results:
- miR-122's function in the liver is well-established.
- The role of miR-122 in extrahepatic tissues is not fully understood.
- miR-122 has potential as a biomarker and drug target.
Conclusions:
- miR-122 is a significant regulator beyond the liver.
- Further research is needed to elucidate extrahepatic functions of miR-122.
- miR-122 holds promise for clinical applications in various diseases.
