Clinical difference between solitary and multiple pulmonary adenocarcinoma nodules
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View abstract on PubMed
Summary
This summary is machine-generated.Multiple primary lung adenocarcinoma nodules show less aggressive biological behavior and a significantly lower risk of lymph node metastasis compared to solitary nodules. This finding aids in clinical diagnosis and treatment strategies for lung cancer.
Area Of Science
- Pulmonology
- Oncology
- Radiology
Background
- Lung adenocarcinoma is a common malignancy.
- Distinguishing between solitary and multiple nodules is crucial for prognosis.
- Understanding biological behavior differences informs treatment.
Purpose Of The Study
- To compare imaging features, tumor markers, immunohistochemistry, and lymph node metastasis rates.
- To analyze differences between solitary and multiple primary lung adenocarcinoma.
- To provide a reference for clinical diagnosis and treatment.
Main Methods
- Retrospective analysis of 212 lung adenocarcinoma patients (2022-2023).
- Propensity score matching to compare solitary (149) and multiple (63) nodules.
- Binary logistic regression to analyze lymph node metastasis risk.
Main Results
- Significant differences found in mean CT value, Ki-67, PD-L1 expression, and lymph node metastasis rates.
- Multiple nodules had an 80.8% lower probability of lymph node metastasis (P=0.042).
- No significant differences in nodule type, imaging features, serological markers, ALK-positive, or SYN-positive rates.
Conclusions
- Multiple primary lung adenocarcinoma nodules demonstrate milder biological behavior.
- Solitary lung adenocarcinoma nodules present a higher risk of lymph node metastasis.
- Findings support differentiated clinical management based on nodule multiplicity.
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