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Normative Values of Brainstem Auditory-Evoked Responses in Sheep.
Katharina Suntinger1, Adrian Dalbert1, Lukas Prochazka1
1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.
Brain Sciences
|January 24, 2025
Summary
This study establishes normative brainstem auditory-evoked response (BAER) values for sheep, demonstrating their similarity to human data. These findings support sheep as a valuable animal model for auditory research.
Area of Science:
- Neuroscience
- Otolaryngology
- Animal Models
Background:
- The brainstem auditory-evoked response (BAER) is crucial for assessing auditory pathway function.
- Normative BAER data are lacking in sheep, a significant animal model for otological research.
- Establishing these values is vital for translational and basic research.
Purpose of the Study:
- To determine normative brainstem auditory-evoked response (BAER) values in sheep.
- To assess the function of the ovine auditory nervous system.
- To compare ovine BAER data with existing human BAER data.
Main Methods:
- Retrospective analysis of BAER data from six sheep (mean age 41.8 months).
- Click stimuli were used across a range of sound pressure levels (SPLs).
- BAER thresholds, latencies, interpeak latencies, and amplitudes were analyzed.
Main Results:
- The mean BAER threshold in sheep was 45.3 dB SPL.
- At 100 dB SPL, mean latencies for wave V, III, and I were 4.35, 2.44, and 0.88 ms, respectively.
- Mean amplitudes at 100 dB SPL were 0.04 µV (wave I), 0.50 µV (wave III), and 0.40 µV (wave V).
Conclusions:
- Reproducible normative BAER values were established for sheep.
- Ovine BAER data closely resemble human BAER data.
- These normative values reinforce the utility of sheep in otological research.
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