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Eco-Friendly Hydrogels Loading Polyphenols-Composed Biomimetic Micelles for Topical Administration of Resveratrol and
Beatriz N Guedes1, Tatiana Andreani2,3, M Beatriz P P Oliveira4
1Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Biomimetics (Basel, Switzerland)
|January 24, 2025
Summary
This study developed antioxidant-loaded hydrogels using natural ingredients for topical delivery. Olive pomace incorporation reduced viscosity without affecting texture, supporting sustainable formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Cosmetic Science
Background:
- Hydrogels offer advantages for topical drug delivery.
- Lipid micelles mimic skin composition, aiding delivery of poorly water-soluble compounds.
- Combining hydrogels and micelles enables effective combination therapy for skin conditions.
Purpose of the Study:
- To develop novel hydrogel formulations incorporating micelles loaded with resveratrol and rutin.
- To evaluate the impact of olive pomace as a sustainable ingredient on formulation properties.
- To assess the rheological and textural characteristics of the developed semi-solid formulations for topical application.
Main Methods:
- Biomimetic micelles of L-α-phosphatidylcholine loaded with resveratrol and rutin were prepared using hot shear homogenization and ultrasonication.
- Micelles were dispersed in carbomer 940-based hydrogels, with some formulations including olive pomace.
- Thermal, rheological, and textural analyses were performed on the developed hydrogel formulations.
Main Results:
- Micelle profiles remained unchanged upon incorporation into hydrogels.
- Rheological analysis confirmed suitable semi-solid properties for topical administration.
- Hydrogels containing olive pomace exhibited lower viscosity than those without, while maintaining firmness and cohesiveness.
Conclusions:
- The developed hydrogel formulations are suitable for topical delivery of antioxidants.
- Olive pomace can be incorporated into hydrogels to modify rheological properties beneficially.
- This approach aligns with zero-waste and circular economy principles in cosmetic and pharmaceutical development.
