Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Resveratrol possesses therapeutic potential but requires effective delivery systems.
• Alginate hydrogels are widely used for drug encapsulation.
• Controlled release mechanisms are crucial for optimizing therapeutic efficacy.

Purpose of the Study:

• To develop alginate-based composite beads for resveratrol delivery.
• To investigate the effect of graphene nanoplatelets on resveratrol release kinetics.
• To evaluate the biocompatibility of the developed drug delivery system.

Main Methods:

• Fabrication of alginate-resveratrol (AR) and alginate-graphene-resveratrol (AGR) beads via ionic cross-linking.
• Characterization of bead formation and resveratrol encapsulation.
• In vitro release studies of resveratrol from beads in phosphate-buffered saline at varying pH.
• Kinetic analysis of drug release profiles.
• Cytotoxicity assessment using normal human cells.

Main Results:

• Graphene incorporation in AGR beads enhanced resveratrol release, particularly at pH 6.8, suggesting a pH-driven release.
• The Higuchi model accurately described the resveratrol release mechanism from the beads.
• Cytotoxicity tests confirmed the biocompatibility of the graphene-enhanced alginate system with normal human cells.

Conclusions:

• Graphene-enhanced alginate matrices are effective for controlled resveratrol delivery.
• The developed system demonstrates pH-dependent release characteristics.
• These findings highlight the potential of graphene-alginate composites for advanced drug delivery applications.