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Research Progress in Small-Molecule Detection Using Aptamer-Based SERS Techniques.

Li Zheng1, Qingdan Ye1, Mengmeng Wang1

  • 1College of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, China.

Biosensors
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

Aptamer-based Surface-Enhanced Raman Scattering (SERS) techniques offer sensitive detection of small molecules like pesticides, antibiotics, and toxins. This review highlights their progress and future potential in various analytical applications.

Keywords:
SERSaptamersensorssmall molecule

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Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Spectroscopy

Background:

  • Nucleic acid aptamers are selected DNA/RNA oligonucleotides that specifically bind target molecules.
  • Surface-Enhanced Raman Scattering (SERS) spectroscopy provides ultra-sensitive, non-destructive molecular fingerprinting.
  • Small molecules like pesticides, antibiotics, and toxins pose risks to health and the environment.

Purpose of the Study:

  • To review the application and progress of aptamer-based SERS techniques for small-molecule detection.
  • To focus on the analysis of pesticide residues, antibiotics, and toxins.
  • To discuss the combined potential and future prospects of these methods.

Main Methods:

  • Selection of nucleic acid aptamers via SELEX technology.
  • Utilizing SERS spectroscopy for sensitive molecular detection.
  • Integrating aptamers as recognition elements with SERS for enhanced analysis.

Main Results:

  • Aptamer-SERS techniques demonstrate high sensitivity and specificity for small-molecule targets.
  • Successful applications shown in detecting pesticide residues, antibiotics, and toxins.
  • The combination of aptamers and SERS offers a powerful analytical platform.

Conclusions:

  • Aptamer-based SERS is a promising approach for the sensitive detection of harmful small molecules.
  • Continued research and development are expected to expand its applications in food safety, environmental monitoring, and biomedicine.
  • The synergy between aptamer recognition and SERS detection holds significant future potential.