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Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

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Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications-A Comprehensive Review.

Muhammad A Butt¹

¹Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland.

|January 24, 2025

Summary

Surface Plasmon Resonance (SPR) biodetection offers real-time, label-free analysis for diagnostics and monitoring. Advancements enhance sensitivity and expand applications in medicine and environmental science.

Keywords:

Surface Plasmon Resonance biodetection systems drug delivery environmental monitoring food safety plasmonics

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Area of Science:

Biotechnology
Analytical Chemistry
Biosensing

Background:

Surface Plasmon Resonance (SPR) is a label-free technique for real-time biomolecular interaction analysis.
SPR leverages evanescent waves and surface plasmons for high sensitivity and specificity in detection.
SPR systems are crucial in diagnostics, drug discovery, and environmental monitoring.

Purpose of the Study:

To review the foundational principles of SPR-based biodetection.
To highlight recent technological advancements and their impact on analytical performance.
To explore the diverse applications and future directions of SPR technology.

Main Methods:

Review of foundational SPR principles, including evanescent waves and surface plasmons.
Discussion of recent technological advancements: sensor chip materials, nanostructures, and complementary techniques.
Exploration of diverse applications: pathogen detection, cancer biomarkers, food safety, and toxin analysis.

Main Results:

SPR technology demonstrates high sensitivity and specificity for biomolecular interactions.
Advancements in materials and nanostructures significantly improve SPR analytical performance.
SPR systems are successfully applied across various fields, including healthcare and environmental monitoring.

Conclusions:

SPR-based biodetection systems are transformative tools with broad applicability.
Ongoing research focuses on miniaturization, cost reduction, and multiplexing for wider adoption.
SPR technology holds significant potential for addressing critical scientific and societal challenges.