Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023

Area of Science:

• Natural Product Chemistry
• Microbiology
• Pharmacology

Background:

• Angucyclines/angucyclinones are polyketides with varied chemical structures.
• These compounds exhibit significant bioactivities, including antibacterial, antifungal, anticancer, anti-neuroinflammatory, and anti-α-glucosidase properties.
• Marine and terrestrial microorganisms are key sources for discovering bioactive angucyclines/angucyclinones.

Purpose of the Study:

• To review and synthesize information on angucyclines/angucyclinones.
• To cover 283 bioactive compounds discovered between 1965 and 2023.
• To emphasize the biological origins, chemical structures, and biological activities of these natural products.

Main Methods:

• Literature review of scientific publications from 1965 to 2023.
• Compilation of data on angucycline/angucyclinone discovery, structure, and bioactivity.
• Categorization of compounds based on their biological origins and activities.

Main Results:

• Identification and summary of 283 distinct bioactive angucyclines/angucyclinones.
• Detailed overview of the structural diversity within this class of compounds.
• Comprehensive cataloging of their reported biological activities, including therapeutic potential.

Conclusions:

• Angucyclines/angucyclinones represent a rich source of diverse bioactive natural products.
• Microorganisms continue to be a vital resource for novel angucycline/angucyclinone discovery.
• Further research into these compounds may yield new therapeutic agents.