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Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines
Aziz A Chentoufi1, Jeffrey B Ulmer2, Lbachir BenMohamed1,2,3
1Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
Vaccines
|January 24, 2025
Summary
Next-generation pan-Coronavirus vaccines are crucial to end the pandemic. Nucleoside-modified mRNA in lipid nanoparticles shows promise for broad immunity against evolving SARS-CoV-2 variants.
Area of Science:
- Virology and Immunology
- Vaccine Development
Background:
- The COVID-19 pandemic persists due to SARS-CoV-2 variants and vaccines that do not prevent transmission.
- A critical need exists for broad-spectrum pan-Coronavirus vaccines to control the pandemic.
Purpose of the Study:
- To review antigen delivery platforms for next-generation pan-Coronavirus vaccines.
- To discuss challenges and highlight promising platforms for durable immunity.
Main Methods:
- Bioinformatics, molecular and structural biology, immunology, and computational methods are employed.
- Review of current antigen delivery platforms and their associated challenges.
Main Results:
- Identifying conserved antigens and effective delivery systems are key for pan-Coronavirus vaccine development.
- Nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNP) is a promising platform.
Conclusions:
- LNPs offer a suitable platform for inducing broad-based, long-lasting immunity against current and future Coronavirus threats.
- This platform supports large-scale manufacturing for durable protective immunity.
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