Jove
Visualize
Contact Us

Related Concept Videos

Vaccinations01:51

Vaccinations

43.9K
Overview
43.9K
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

70.2K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
70.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary diversity and structural dynamics of the outer membrane protein Ail in <i>Yersinia</i>.

Journal of biomolecular structure & dynamics·2026
Same author

Virulence Reduction in <i>Yersinia pestis</i> by Combining Delayed Attenuation with Plasmid Curing.

Biomolecules·2026
Same author

Protection Elicited by Glutamine Auxotroph of <i>Yersinia pestis</i>.

Vaccines·2025
Same author

Complete genome assembly of <i>Yersinia alsatica</i> SCPM-O-B-7604.

Microbiology resource announcements·2025
Same author

Genetically Engineered Bacterial Ghosts as Vaccine Candidates Against <i>Klebsiella pneumoniae</i> Infection.

Vaccines·2025
Same author

Evaluation of 16S rRNA genes sequences and genome-based analysis for identification of non-pathogenic <i>Yersinia</i>.

Frontiers in microbiology·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 31, 2025

'Bioluminescent' Reporter Phage for the Detection of Category A Bacterial Pathogens
11:31

'Bioluminescent' Reporter Phage for the Detection of Category A Bacterial Pathogens

Published on: July 8, 2011

13.4K

Live Plague Vaccine Development: Past, Present, and Future.

Andrey P Anisimov1, Anastasia S Vagaiskaya1, Alexandra S Trunyakova1

  • 1Laboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia.

Vaccines
|January 24, 2025
PubMed
Summary

Modern vaccine design uses rational approaches, focusing on antigen and adjuvant selection for improved immunogenicity and safety. This review discusses developing live plague vaccines for enhanced protection across diverse populations.

Keywords:
Yersinia pestislive vaccineplague vaccine

More Related Videos

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.1K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

21.8K

Related Experiment Videos

Last Updated: May 31, 2025

'Bioluminescent' Reporter Phage for the Detection of Category A Bacterial Pathogens
11:31

'Bioluminescent' Reporter Phage for the Detection of Category A Bacterial Pathogens

Published on: July 8, 2011

13.4K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.1K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

21.8K

Area of Science:

  • Vaccinology
  • Immunology
  • Microbiology

Background:

  • Vaccine development has shifted from empirical methods to rational design, emphasizing antigen and adjuvant selection for efficacy.
  • Modern vaccine design requires considering factors beyond target antigens to optimize immunogenicity and safety.
  • Recent advancements enable custom-designed vaccines tailored to diverse population responses.

Purpose of the Study:

  • To review strategies for developing live, safe, and protective human plague vaccines.
  • To discuss tactics for enhancing vaccine protection duration and breadth against virulent strains.
  • To consider diverse host factors, including age, gender, and genetic variations, in vaccine development.

Main Methods:

  • Review of recent literature on plague vaccine development, focusing on live vaccine approaches.
  • Analysis of strategies for improving vaccine efficacy, safety, and duration of protection.
  • Consideration of host-specific factors influencing immune responses to vaccination.

Main Results:

  • Live plague vaccines are increasingly being developed, complementing traditional subunit vaccines.
  • Rational vaccine design allows for tailored approaches to improve immunogenicity and safety.
  • Optimized vaccine strategies can enhance protection breadth and duration against various plague strains.

Conclusions:

  • Live plague vaccines offer a promising avenue for enhanced and broader protection.
  • Custom-designed vaccines considering host genetics and demographics are crucial for optimal efficacy.
  • Continued research into rational vaccine design is essential for addressing challenging pathogens and populations.