Progress in injectable hydrogels for hard tissue regeneration in the last decade

Bone disorders have increased with increasing the human lifespan, and despite the tissue's ability to self-regeneration, in many congenital problems and hard fractures, bone grafting such as autograft, allograft, and biomaterials implantation through surgery is traditionally used. Because of the adverse effects of these methods, the emergence of injectable hydrogels without the need for surgery and causing more pain for the patient is stunning to develop a new pattern for hard tissue engineering. These materials are formed with various natural and synthetic polymers with a crosslinked network through various chemical methods such as click chemistry, Michael enhancement, Schiff's base and enzymatic reaction and physical interactions with high water absorption which can mimic the environment of cells. The purpose of this research is to review the capabilities of this class of materials in hard tissue regeneration in the last decade through adaptable physical and chemical properties, the ability to fill defect sites with an irregular shape, and the ability to grow hormones or release drugs, in response to external stimuli.