Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A novel approach to radioembolization treatment planning using a hybrid [<sup>99m</sup>Tc]Tc-MAA contrast enhanced SPECT/CT.

European journal of nuclear medicine and molecular imaging·2026

Same author

Radioligand therapy for paediatric patients with solid tumours.

The British journal of radiology·2026

Same author

Somatostatin receptor PET response assessment framework for patients with neuroendocrine tumours (V1.0): a modified Delphi consensus from the European Neuroendocrine Tumor Society (endorsed by EANM and NANETS).

The Lancet. Oncology·2026

Same author

Fatigue after pediatric bone sarcoma: prevalence and associated factors in pediatric and adult patients and survivors after treatment.

Journal of cancer survivorship : research and practice·2026

Same author

European guideline for imaging of primary paediatric and adult osteosarcoma and Ewing sarcoma: systematic review and joint statement by the FOSTER consortium, Euro Ewing Consortium, European Society of Paediatric Radiology, and the European Association of Nuclear Medicine.

The Lancet. Oncology·2026

Same author

Fraction-dependent dose dynamics and clinical safety in high-risk neuroblastoma treated with [<sup>177</sup>Lu]Lu-DOTATATE: results from the LuDO-N trial.

European journal of nuclear medicine and molecular imaging·2026

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

The prognostic value of baseline EARL standardized FDG PET indices in pediatric and adolescent high-grade

Roelof van Ewijk¹, Rana Dandis², Janna Rodewijk²

¹Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. r.vanewijk-2@prinsesmaximacentrum.nl.

European Radiology

|January 24, 2025

Summary

Baseline [18F]fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) markers do not predict survival in pediatric osteosarcoma. Proposed cutoff values from prior studies lack validation and show technical issues, limiting clinical use for event-free survival (EFS) and overall survival (OS).

Keywords:

Osteosarcoma PET-CT Pediatrics Prognostic factors Quality control.

More Related Videos

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Related Experiment Videos

Last Updated: Jun 21, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Area of Science:

Oncology
Nuclear Medicine
Radiology

Background:

High-grade osteosarcoma is a challenging pediatric cancer.
Prognostic value of baseline [18F]fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging markers for survival in osteosarcoma requires validation.
European Association of Nuclear Medicine Research Ltd. (EARL) standardization ensures consistent PET-CT data acquisition and analysis.

Purpose of the Study:

To assess the prognostic significance of baseline EARL-standardized [18F]FDG PET-CT quantitative values for event-free survival (EFS) and overall survival (OS) in pediatric and adolescent osteosarcoma patients.
To evaluate previously reported cutoff values for [18F]FDG PET-CT indices in this patient cohort.

Main Methods:

Retrospective analysis of 66 pediatric and adolescent patients with high-grade osteosarcoma.
Baseline [18F]FDG PET-CT with EARL-accredited reconstructions was used for staging.
Cox proportional hazard analysis and Kaplan-Meier analysis were employed to evaluate prognostic factors and PET-CT indices for EFS and OS.

Main Results:

Baseline standardized uptake value (SUV) peak, total lesion glycolysis (TLG), and metabolic tumor volume (MTV) were not prognostic for EFS or OS in univariable Cox regression.
Log-rank analysis indicated significant differences in EFS for SULmax and SULpeak cutoffs, and for MTVtotal and TLGtotal using specific cutoff strategies.
No tested cutoff for any [18F]FDG PET-CT index demonstrated a significant difference in OS between patient groups.

Conclusions:

Baseline EARL-standardized [18F]FDG PET-CT indices are not prognostic for EFS or OS in pediatric and adolescent osteosarcoma.
Proposed prognostic cutoffs from previous studies exhibit technical and statistical limitations, questioning their clinical applicability.
The heterogeneity in identified cutoffs and lack of robust validation impede the clinical implementation of [18F]FDG PET-CT markers for osteosarcoma prognostication.