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Updated: May 31, 2025
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Published on: February 17, 2023
Trichogerminoma with malignant transformation
Thibault Kervarrec1,2,3, Maxence Mancini4, Anne Tallet5
1Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France. thibaultkervarrec@yahoo.fr.
Abstract:
Trichogerminoma (TG) is a rare adnexal tumor with hair follicle differentiation with less than 50 cases reported in the literature. In 2022, by investigating the genetic profile of 21 cases, our group identified recurrent rearrangements of the GRHL1/2/3 genes in this tumor entity, suggesting such alteration as the main oncogenic driver in TG. Up to now, only one TG case of malignant transformation has been reported. In the present letter, we report a second case of TG with malignant transformation and provide molecular characterization of this tumor.
Insights
Trichogerminoma, a rare hair follicle tumor, often shows GRHL gene rearrangements. This study details a second reported case of malignant trichogerminoma with molecular analysis.
Area of Science:
- Dermatopathology
- Oncology
- Genetics
Background:
- Trichogerminoma (TG) is an exceptionally rare adnexal neoplasm.
- Fewer than 50 cases of TG have been documented globally.
- Recurrent GRHL1/2/3 gene rearrangements were previously identified as the primary oncogenic driver in TG.
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