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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
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Mandibular hybrid odontogenic tumor.

Fernanda Brasil Daura Jorge Boos-Lima1,2, Talita de Carvalho Kimura3, Flávia Akemi Nakayama Henschel3

  • 1Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA. fernandabooslima@gmail.com.

Oral and Maxillofacial Surgery
|January 24, 2025
PubMed
Summary

This case report details the first mandibular hybrid odontogenic tumor (HOT) comprising ameloblastoma, calcifying epithelial odontogenic tumor, and ameloblastic fibroma. Early diagnosis and comprehensive surgical management are crucial for favorable outcomes in these rare complex lesions.

Keywords:
Ameloblastic fibromaAmeloblastomaCase reportOdontogenic tumorsPindborg tumor

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pathology
  • Oncology

Background:

  • Hybrid Odontogenic Tumors (HOT) are characterized by the coexistence of two or more distinct odontogenic tumor types within the same maxillofacial region.
  • These complex lesions present diagnostic and therapeutic challenges due to their rarity and varied histological components.

Purpose of the Study:

  • To report the first case of a mandibular hybrid odontogenic tumor (HOT) involving Ameloblastoma, Calcifying Epithelial Odontogenic Tumor, and Ameloblastic Fibroma.
  • To highlight the diagnostic considerations and surgical management of such rare complex odontogenic pathologies.

Main Methods:

  • A comprehensive clinical presentation of a 37-year-old male with a mandibular swelling is described.
  • Diagnostic imaging included computed tomography (CT) to delineate the osteolytic, multilocular, and expansile lesion.
  • Surgical resection via an intraoral approach with a 1 cm safety margin, followed by microvascularized fibula flap reconstruction.

Main Results:

  • The patient presented with a large, expansile mandibular lesion involving multiple odontogenic tumor types.
  • Successful surgical resection and reconstruction were achieved.
  • A ten-year follow-up confirmed no recurrence of the hybrid odontogenic tumor.

Conclusions:

  • Hybrid odontogenic tumors, though rare, must be considered in the differential diagnosis of extensive odontogenic pathologies.
  • Thorough histopathological examination with multiple biopsies is essential for accurate diagnosis due to microscopic variability.
  • Understanding the pathogenesis and pathophysiology is key to improving treatment strategies and surgical outcomes for HOTs.