Classification and treatment approach of chemical burn associated Limbal stem cell deficiency: based on novel global...

To evaluate the severity distribution of chemical burn-induced Limbal stem cell deficiency (LSCD) according to the novel global consensus classification and to compare the treatment approach, before and after the global consensus.

Medical records of 127 eyes of 109 patients with LSCD were included. LSCD stages were categorized according to the global consensus classification published by "International LSCD Working Group".

The mean age was 37.5 ± 16.5(6-75). The distribution of LSCD stage according to the global consensus scale was as follows: Stage 1A in 5 eyes(3.9%);Stage 1B in 16 eyes(12.6%);Stage 1C in 4 eyes(3.2%);Stage 2A in 15 eyes(11.8%);Stage 2B in 36 eyes(28.3%);Stage 3 in 51 eyes(40.2%). A total of 88(69.3%) eyes underwent surgery for LSCD. Of these, 80 had surgery prior to the publication of the global consensus (before October 2020), 58(72.5%) had preoperative severe (≥ Stage 2B) LSCD and 22(27.5%) had preoperative early stage (≤ Stage 2A) LSCD. As of October 2020, all 8 eyes that underwent surgery had preoperative severe (≥ Stage 2B) LSCD, as recommended by global consensus.

Recently, a global consensus has been established on both the classification and the management of LSCD. This study is one of the first to present small-scale epidemiological data on the severity distribution of LSCD in the light of the global consensus. It was observed that surgery was performed on 27.5% of the eyes that were not recommended for surgery according to this new consensus. With the increasing awareness of this consensus, it might be possible to avoid unnecessary surgical intervention.