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Related Concept Videos

Master Transcription Regulators02:23

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Covalently Linked Protein Regulators02:04

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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Updated: May 31, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
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METTL3: a multifunctional regulator in diseases.

Na Li1, Xiang Wei1, Jian Dai2

  • 1Division of Cardiothoracic and Vascular Surgery, Sino-Swiss Heart-Lung Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Molecular and Cellular Biochemistry
|January 24, 2025
PubMed
Summary

N6-methyladenosine (m6A) methylation, regulated by Methyltransferase-like 3 (METTL3), plays a key role in various diseases. METTL3 shows promise as a therapeutic target and diagnostic biomarker for conditions like cancer and metabolic disorders.

Keywords:
CancerCardiovascular diseasesDrug therapyMETTL3Metabolic diseasesm6A

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Area of Science:

  • Molecular Biology
  • Epigenetics
  • RNA Biology

Background:

  • N6-methyladenosine (m6A) is the most abundant internal mRNA modification, crucial for gene regulation.
  • Methyltransferase-like 3 (METTL3) is the primary enzyme catalyzing m6A methylation.
  • Aberrant METTL3 expression is linked to numerous pathological conditions, including metabolic diseases, cardiovascular diseases, and cancer.

Purpose of the Study:

  • To review the regulatory functions of METTL3 in various diseases.
  • To highlight recent advancements in identifying METTL3's downstream target genes and molecular mechanisms.
  • To discuss the potential of METTL3 as a therapeutic target and diagnostic biomarker.

Main Methods:

  • Literature review of recent studies on METTL3 function and regulation.
  • Analysis of METTL3's role in metabolic diseases, cardiovascular diseases, and cancer.
  • Examination of molecular mechanisms and regulators of METTL3 expression and activity.

Main Results:

  • METTL3 regulates diverse functional genes across multiple disease systems.
  • METTL3's methyltransferase activity and mRNA posttranslational modifications are key to its regulatory mechanisms.
  • METTL3 is implicated in the pathogenesis of metabolic diseases, cardiovascular diseases, and cancer.

Conclusions:

  • METTL3 is a multifunctional regulator with significant roles in various diseases.
  • Understanding METTL3's downstream targets and regulatory mechanisms is crucial for therapeutic development.
  • METTL3 presents considerable potential as a novel diagnostic biomarker and therapeutic target.