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Realistic total-body J-PET geometry optimization: Monte Carlo study.

Jakub Baran1,2,3, Wojciech Krzemien2,3,4, Szymon Parzych1,2,3

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Summary
This summary is machine-generated.

The Jagiellonian PET (J-PET) technology offers a cost-effective total-body PET scanner. Seven-ring J-PET designs show superior imaging but are more expensive than three-ring options, balancing performance and cost for clinical applications.

Keywords:
J‐PETMonte Carlo simulationsTB PET

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Area of Science:

  • Medical Imaging Physics
  • Nuclear Instrumentation
  • Positron Emission Tomography

Background:

  • Total-body (TB) Positron Emission Tomography (PET) offers advancements in personalized medicine and low-dose imaging.
  • Current TB PET scanners are expensive due to inorganic scintillators, limiting accessibility.
  • Jagiellonian PET (J-PET) technology utilizes plastic scintillators for a lower-cost TB PET solution.

Purpose of the Study:

  • To compare five total-body J-PET scanner geometries for multi-organ and positronium imaging.
  • To evaluate potential next-generation J-PET scanner designs.
  • To assess the trade-offs between performance and cost in J-PET scanner development.

Main Methods:

  • In silico investigation of five TB J-PET geometries using Monte Carlo simulations.
  • Performance assessment with XCAT phantom, sensitivity line source, and positronium phantoms.
  • Quantitative analysis of image quality metrics (contrast recovery, background variability, RMSE) and cost analysis.

Main Results:

  • Seven-ring J-PET scanners demonstrated superior image quality compared to three-ring setups.
  • Three-ring scanners are approximately 2-3 times cheaper than seven-ring configurations.
  • Peak sensitivities for two-gamma imaging ranged from 20-34 cps/kBq, with positronium imaging sensitivities 20-28 times lower.

Conclusions:

  • All evaluated J-PET systems are feasible for multi-organ imaging, with axial field-of-view being a critical parameter.
  • Seven-ring scanners offer better sensitivity and image reconstruction, but at a higher cost.
  • J-PET technology presents a cost-effective, attractive option for broad clinical applications, including positronium imaging.