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Optimizing orthobiologic therapies with exercise, diet, and supplements.

Jami Montagnino1,2, Matthew W Kaufman1,3, Maya Shetty1,3

  • 1Department of Orthopaedic Surgery, Stanford University, Redwood City, California, USA.

PM & R : the Journal of Injury, Function, and Rehabilitation
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Summary
This summary is machine-generated.

Lifestyle choices like exercise, diet, and supplements can significantly impact the effectiveness of orthobiologic injections such as platelet-rich plasma (PRP) and cell-based therapies. Optimizing these factors may enhance treatment outcomes.

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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Sports Medicine

Background:

  • Orthobiologic injections, including platelet-rich plasma (PRP) and cell-based therapies, are gaining traction for musculoskeletal conditions.
  • Their clinical success may hinge on the quality of the biological material used for injection.

Purpose of the Study:

  • To explore the potential influence of lifestyle factors on the efficacy of orthobiologic injections.
  • To review how exercise, diet, and supplements might modulate the quality of PRP and mesenchymal stromal cells (MSCs).

Main Methods:

  • Literature review examining the relationship between lifestyle modifications and orthobiologic injectate quality.
  • Analysis of studies on platelet function, MSC senescence, replication, and differentiation in response to lifestyle interventions.

Main Results:

  • Exercise may enhance platelet count, activity, and growth factor release, while potentially limiting cellular senescence in MSCs.
  • Anti-inflammatory diets appear to improve platelet parameters, whereas high-stress or high-sugar diets may negatively impact injectate quality.
  • Certain supplements and dietary changes (e.g., lower calorie intake) might influence MSC viability and function.

Conclusions:

  • Biologic plausibility exists for exercise, diet, and supplements to affect orthobiologic injection efficacy.
  • Further translational research is required to quantify these effects and establish clinical guidelines.