Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Computationally-efficient linear scheme for overlap time-gating spatial frequency domain diffuse optical tomography using an analytical diffusion model.

Biomedical optics express·2024

Same author

Deep-learning approach to stratified reconstructions of tissue absorption and scattering in time-domain spatial frequency domain imaging.

Journal of biomedical optics·2024

Same author

A combined autofluorescence and diffuse reflectance spectroscopy for mucosa tissue diagnosis: Dual-distance system and data-driven decision.

Journal of biophotonics·2023

Same author

CGAN-rIRN: a data-augmented deep learning approach to accurate classification of mental tasks for a fNIRS-based brain-computer interface.

Biomedical optics express·2023

Same author

Neural network-based optimization of sub-diffuse reflectance spectroscopy for improved parameter prediction and efficient data collection.

Journal of biophotonics·2023

Same author

Deep-learning informed Kalman filtering for priori-free and real-time hemodynamics extraction in functional near-infrared spectroscopy.

Biomedical optics express·2022

Search research articles

Related Experiment Video

Updated: May 31, 2025

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

Enhancing Functional Breast Imaging: A sCMOS Camera-Based Lock-in Implementation for Dynamic Tomography.

Yujie Zheng¹, Limin Zhang¹, Weijie Song²

¹The College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, China.

Journal of Biophotonics

|January 24, 2025

Summary

This study introduces a camera-based dynamic diffuse optical tomography (DOT) system for improved breast cancer screening. The novel approach enhances signal-to-noise ratio for more sensitive detection of oxy- and deoxy-hemoglobin.

Keywords:

camera‐based lock‐in detection diffuse optical tomography early‐stage diagnosis breast cancer orthogonal frequency division multiplexing technology

More Related Videos

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Related Experiment Videos

Last Updated: May 31, 2025

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Area of Science:

Biomedical Optics
Medical Imaging
Cancer Diagnostics

Background:

Diffuse optical tomography (DOT) quantifies tissue chromophores like oxy- and deoxy-hemoglobin (HbO and HbR).
Accurate quantification is crucial for detecting and predicting neoadjuvant breast cancer treatment response.
Existing DOT systems face limitations in channel count (fiber-dependent) and signal-to-noise ratio (camera-dependent).

Purpose of the Study:

To develop a camera-based dynamic DOT system with enhanced signal-to-noise ratio (SNR).
To overcome limitations of current fiber-dependent and camera-dependent DOT systems for breast cancer screening.
To enable sensitive and dynamic tomography for improved breast cancer detection.

Main Methods:

Implemented a camera-based lock-in detection scheme.
Utilized orthogonal frequency division multiplexing technology for dynamic DOT.
Evaluated system performance using tissue phantoms and neoplastic rat models.

Main Results:

The developed system achieves parallel measurement using a camera detector.
Demonstrated a significant improvement in signal-to-noise ratio (SNR) for dynamic DOT.
Showcased high sensitivity and dynamic imaging capabilities for breast screening.

Conclusions:

The camera-based dynamic DOT system offers a promising advancement for breast cancer screening.
The system provides highly sensitive and dynamic tomography, addressing limitations of previous DOT technologies.
This technology has the potential to improve early detection and treatment response assessment in breast cancer.