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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
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Photoredox-Mediated Immunotherapy Utilizing Rhenium(I) Photocatalysts with Electron Donor-Acceptor-Donor
Dan Li1, Guoqing Wen1, Haobing Wang1
1College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.
Journal of Medicinal Chemistry
|January 24, 2025
Summary
This study introduces novel rhenium(I) complexes for photodynamic therapy in hypoxic tumors. These photosensitizers trigger ferroptosis and immunotherapy, effectively suppressing tumor growth.
Area of Science:
- Inorganic Chemistry
- Photochemistry
- Cancer Therapy
Background:
- Hypoxic tumors limit oxygen-dependent photodynamic therapy efficacy.
- Photoredox catalysis offers a promising strategy to overcome hypoxia-induced limitations.
- Efficient photosensitizers are crucial for advanced cancer treatments.
Purpose of the Study:
- To design and synthesize novel rhenium(I) tricarbonyl complexes for photodynamic therapy.
- To investigate the photophysical properties and photosensitizing capabilities of these complexes.
- To evaluate their therapeutic efficacy against hypoxic tumors via photoredox catalysis.
Main Methods:
- Rational design of rhenium(I) tricarbonyl complexes (Re-TPO and Re-TP) with D-A-D configuration.
- Characterization of aggregation-induced emission and spin-orbit coupling properties.
- Assessment of reactive oxygen species generation, metabolic intervention (NADH/NAD+, pyruvate/lactate), and tumor suppression in vivo.
Main Results:
- Re-TP demonstrated enhanced photosensitizing capability due to aggregation-induced emission and increased spin-orbit coupling.
- Excited Re-TP induced type I and II reactive oxygen species, oxidized NADH, and reduced pyruvic acid.
- Metabolic disruption triggered PD-L1 immune responses, ferroptosis, and immunogenic cell death, suppressing B16 tumors.
Conclusions:
- The developed rhenium(I) complexes, particularly Re-TP, show significant potential as photosensitizers for photoredox-mediated photoimmunotherapy.
- This approach effectively combats hypoxic tumors by combining ferroptosis and immunotherapy.
- The study presents a valuable model for designing metal-based photosensitizers for challenging tumor microenvironments.
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