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Related Concept Videos

Body Water Content and Fluid Compartments01:19

Body Water Content and Fluid Compartments

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Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
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Related Experiment Video

Updated: May 5, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

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Reference Values for Water-Specific T1, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.89 T.

Stephen J Foulkes1,2, Mark J Haykowsky1, Rachel Sherrington3

  • 1Integrated Cardiovascular Exercise Physiology and Rehabilitation Lab, College of Health Sciences, Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.

Journal of Magnetic Resonance Imaging : JMRI
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

A new MRI technique accurately measures skeletal muscle fat and T1 values, showing higher T1 values in females but no age dependence. This method provides reliable quantification for assessing muscle health.

Keywords:
MOLLIMRIPDFFSASHASR‐CSET1 mappingskeletal muscle

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Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
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Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
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Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Radiology

Background:

  • MRI enables quantification of proton density fat fraction (PDFF) and T1 mapping for tissue characteristics.
  • The impact of age, sex, and fat on skeletal muscle T1 values in healthy adults requires further investigation.

Purpose of the Study:

  • To assess the accuracy and repeatability of a saturation-recovery chemical-shift encoded multiparametric approach (SR-CSE) for T1Water and muscle fat quantification.
  • To establish normative T1Water and muscle fat values in a healthy cohort, considering age and sex.

Main Methods:

  • Prospective observational study involving phantoms and 130 healthy adults (18-76 years).
  • Utilized a 2.89 T MRI scanner with gradient echo sequences, including SR-CSE T1 mapping, MOLLI, SASHA, CSE, and single voxel spectroscopy.
  • Statistical analysis included univariable/multivariable linear regression and Bland-Altman methods.

Main Results:

  • SR-CSE demonstrated excellent accuracy and repeatability (CVs 0.2%-2.6%) for T1Water and PDFF quantification.
  • Mean T1Water was higher in females (1445 msec) vs. males (1409 msec), with no age effect.
  • Females exhibited higher intermuscular (10.4%) and intramuscular fat (2.6%), increasing with age due to lower muscle volume.

Conclusions:

  • SR-CSE offers accurate and repeatable assessment of T1Water and muscle/fat volumes.
  • Conventional methods (SASHA, MOLLI) exhibit significant fat-modulated T1 bias.
  • T1Water values are higher in females, independent of age.