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Related Experiment Video

Updated: May 31, 2025

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
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Bioprinted optoelectronically active cardiac tissues.

Faheem Ershad1,2,3, Zhoulyu Rao4,5, Sushila Maharajan6

  • 1Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.

Science Advances
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed printable, light-stimulable cardiac tissues using optoelectronically active scaffolds. This noninvasive method enables wireless control of heart tissue beating, offering a promising new therapy for cardiac conditions.

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Optoelectronics

Background:

  • Electrical stimulation of bioprinted tissues is limited by invasive methods and potential cell damage.
  • Current cardiac modulation therapies often require wired electrodes and genetic modifications.

Purpose of the Study:

  • To develop a wireless, noninvasive method for controlling cardiac tissue activity.
  • To create light-stimulable, optoelectronically active tissues for cardiac modulation.

Main Methods:

  • Fabrication of a gelatin methacryloyl scaffold embedded with micro-solar cells.
  • Seeding the scaffold with cardiomyocytes to form optoelectronically active tissues.
  • Optoelectronic stimulation using pulsed light to modulate cardiac beating.

Main Results:

  • Light stimulation increased cardiomyocyte beating rates by over 40%.
  • Maintained high cell viability (>96%) during light stimulation.
  • Demonstrated successful acceleration of heart beating in vivo in rats.

Conclusions:

  • Optoelectronically active scaffolds enable untethered, noninvasive, and damage-free modulation of cardiac tissues.
  • This technology offers a printable and optically controllable solution for future therapies of electrically active tissues.
  • The developed optoelectronically active tissues represent a significant advancement in wireless cardiac modulation.