Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neuroleptic malignant syndrome.

M L Martin, E J Lucid, R W Walker

Annals of Emergency Medicine

|April 1, 1985

Summary

This summary is machine-generated.

A 35-year-old man experienced neuroleptic malignant syndrome (NMS) from haloperidol. Supportive care was crucial for his recovery, highlighting the severity of this adverse drug reaction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of strain rate on tensile test results in hydrogen and other concerns.

Engineering fracture mechanics·2026

Same author

Multicenter Automated Central Vein Sign Detection Performs as Well as Manual Assessment for the Diagnosis of Multiple Sclerosis.

AJNR. American journal of neuroradiology·2024

Same author

Modification to a testing assembly to enable strain-life measurements in pressurized hydrogen gas.

The Review of scientific instruments·2023

Same author

Endocarditis caused by <i>Neisseria bacilliformis</i>: a case report and review of literature.

IDCases·2023

Same author

Influence of H<sub>2</sub>S on the pitting corrosion of 316L stainless steel in oilfield brine.

Corrosion science·2021

Same author

The provision of a time-critical elective surgical service during the COVID-19 Crisis: a UK experience.

Annals of the Royal College of Surgeons of England·2021

Same journal

Variation in Emergency Department Experience With Pediatric Critical Illness.

Annals of emergency medicine·2026

Same journal

Point-of-Care Ultrasound-Guided Hydrostatic Reduction of Ileocolic Intussusception in the Pediatric Emergency Department.

Annals of emergency medicine·2026

Same journal

Managing Diabetic Ketoacidosis.

Annals of emergency medicine·2026

Same journal

Needle Thoracostomy: Implications of Chest Wall Thickness for Anatomical Location and Needle Length.

Annals of emergency medicine·2026

Same journal

Women Emergency Physicians and Gender Disparities from Entry to Advancement.

Annals of emergency medicine·2026

Same journal

Policy Statements Approved March 2026.

Annals of emergency medicine·2026

See all related articles

Area of Science:

Neuroscience
Pharmacology

Background:

Neuroleptic Malignant Syndrome (NMS) is a rare but life-threatening reaction to antipsychotic medications.
Haloperidol, a typical antipsychotic, is frequently implicated in NMS cases.

Observation:

A 35-year-old male presented with symptoms of NMS, including coma, hypotension, rigidity, and hyperthermia (42.2°C).
The patient was receiving moderately high, therapeutic doses of haloperidol.

Findings:

The patient required intensive care, including intubation and mechanical ventilation, due to the severity of NMS.
Disseminated intravascular coagulation (DIC) developed and was successfully managed.
The patient recovered with supportive care alone, without specific NMS pharmacotherapies like bromocriptine or dantrolene.

Related Experiment Videos

Implications:

This case underscores the importance of recognizing and managing NMS, even with standard haloperidol doses.
Prompt supportive care is critical for patient survival and recovery from severe NMS.
The case highlights that recovery is possible with intensive supportive measures, even when advanced therapies are not utilized.