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In vivo CRISPR Activation Screening, a Powerful Tool to Discover Oncogenic Driver Genes in Hepatocellular Carcinoma

Shaimaa Gad1, Ruisong Ye2, Wei Qiu2

  • 1Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois; Department of Cancer Biology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois; Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Center, Giza, Egypt.

Cellular and Molecular Gastroenterology and Hepatology
|January 24, 2025
PubMed
Abstract

No abstract available in PubMed .

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...