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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jun 16, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Fingolimod and risk of skin cancer among individuals with multiple sclerosis: a population-based cohort study

Analisa Jia1,2, Lisa Kuramoto3, Amir Khakban1

  • 1Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

BMJ Open
|January 24, 2025
PubMed
Summary

This study outlines a protocol to investigate if fingolimod, a multiple sclerosis (MS) treatment, increases skin cancer risk. Using Canadian health data, it compares fingolimod users to those on other MS drugs to assess safety outcomes.

Keywords:
DERMATOLOGYDrug TherapyDrug UtilisationMultiple sclerosisONCOLOGY

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Area of Science:

  • Neurology
  • Dermatology
  • Pharmacoepidemiology

Background:

  • Multiple sclerosis (MS) treatments require long-term safety evaluation.
  • Fingolimod is an MS medication with a need for comprehensive safety data regarding skin cancer.
  • Advanced causal inference methods are crucial for robust safety studies in real-world populations.

Purpose of the Study:

  • To describe a protocol for investigating the association between fingolimod use and skin cancer incidence in individuals with MS.
  • To establish a framework for evaluating long-term safety outcomes of disease-modifying therapies for MS.
  • To inform clinical decision-making regarding MS treatment safety profiles.

Main Methods:

  • An observational cohort study using a 'trial emulation' design with an active comparator and new-user approach.
  • Utilizing population-based administrative health data from British Columbia and Alberta, Canada.
  • Employing survival analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for skin cancer incidence, adjusted for confounders.

Main Results:

  • This section is not applicable as the abstract describes a study protocol, not results.
  • N/A
  • N/A

Conclusions:

  • This protocol provides a robust design to investigate potential links between fingolimod and skin cancer in MS patients.
  • The findings will contribute essential safety information for fingolimod and other MS therapies.
  • Dissemination through presentations and publications will share knowledge on MS treatment safety.