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Cytogenetic markers in newborns of mothers with comorbidities

Aline C B Pinho1, Ana Beatriz M Baston1, Rita de Cássia F B Fontes2

  • 1Department of Medicine, University of Franca, SP, Brazil.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
|January 24, 2025
PubMed

We have studied the presence and frequency of micronuclei in exfoliated oral mucosa cells of full-term newborns and their association with maternal prenatal factors. We report an analytical, observational, cross-sectional, prospective study that includes 97 preterm infants (<37 weeks), 37 newborns from mothers with comorbidities, and 60 newborns from mothers without comorbidities, in a tertiary public hospital. Oral mucosa cells were collected within 24 h after birth. The frequency of cells with micronuclei and karyolytic cells was significantly higher in the group whose mothers had some form of comorbidity. Mothers with comorbidities had a shorter gestational age; the number of cells with micronuclei was higher in mothers with preterm premature rupture of membranes; and there were fewer karyolytic cells.

Keywords:
CytogeneticsGenotoxicityMicronucleiNeonates

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