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Updated: Aug 2, 2026
12:23
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
Ocular palsy preceding chronic relapsing polyneuropathy by several weeks
Annals of Neurology
|January 1, 1985
Summary
This study describes a rare form of chronic relapsing polyneuritis where eye muscle paralysis preceded limb neuropathy. Patients experienced relapsing symptoms and incomplete recovery despite treatment.
Area of Science:
- Neurology
- Neuroimmunology
Background:
- Chronic relapsing polyneuritis (CR P) can present with diverse neurological deficits.
- Understanding atypical presentations is crucial for accurate diagnosis and management.
Observation:
- Three patients presented with an unusual variant of chronic relapsing polyneuritis.
- Extraocular muscle palsies preceded limb neuropathy by weeks to months.
- Symptoms included dysphagia, areflexia, sensory loss, and limb weakness.
Findings:
- Peripheral neuropathy evolved over 7-12 weeks and relapsed in all cases.
- Electrophysiological studies showed slowed motor nerve conduction and prolonged F wave latencies.
- Cerebrospinal fluid analysis revealed elevated protein without pleocytosis.
Implications:
- This variant highlights the varied clinical manifestations of chronic relapsing polyneuritis.
- Early recognition of preceding extraocular palsies may aid in timely diagnosis.
- Prognosis remains guarded, with incomplete recovery even after immunosuppressive therapy.
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